![]() There is evidence that surgical resection is the treatment of choice for pulmonary metastases from soft tissue sarcoma. 2 Although pulmonary metastases most commonly arise from primary tumors in the extremities, they may arise from almost any histologic variant or primary site. Of patients with extremity sarcoma, approximately 20% will have isolated pulmonary metastatic disease at some point in the course of their disease. The lungs are the most common sites of metastatic disease. Despite progress in multimodality treatment, more than 4000 Americans will die each year of soft tissue sarcoma. 1 Sarcoma may arise virtually anywhere, but the extremity is the most common primary site. ![]() Keratin markers can be useful to identify a tumor of epithelial origin and exclude lymphomas and sarcomas.Soft tissue sarcoma is a rare neoplasm: there are approximately 6600 cases annually in the United States. Useful immunohistochemical markers include chromogranin and synaptophysin, though SCLC is a high-grade neuroendocrine tumor and does not typically express these proteins as highly as would be seen in a low-grade neuroendocrine tumor, such as a carcinoid tumor. Large cell neuroendocrine carcinoma (LCNEC) is classified as a non-small cell lung cancer but has similar biology, behavior, and natural history as SCLC. SCLC is most aggressive of a spectrum of neuroendocrine tumors of the lungs, including typical carcinoid tumors, atypical carcinoids, and large cell neuroendocrine carcinoma. The cells are round, oval, and spindle-shaped and nuclear molding is prominent. Small cell carcinoma is a malignant epithelial tumor consisting of small cells with scant cytoplasm, ill-defined cell borders, finely granular nuclear chromatin, and absent or inconspicuous nucleoli.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |